{"id":1261,"date":"2023-05-18T10:50:44","date_gmt":"2023-05-18T14:50:44","guid":{"rendered":"https:\/\/lightersideofcancer.com\/?page_id=1261"},"modified":"2023-05-23T14:34:53","modified_gmt":"2023-05-23T18:34:53","slug":"clinical-trials","status":"publish","type":"page","link":"https:\/\/lightersideofcancer.com\/clinical-trials\/","title":{"rendered":"Clinical Trials"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\"pexels-artem-podrez-5726706\"\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Clinical Trials<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tAn important component of cancer research comes from clinical trials, which are supervised cancer research studies to determine the effectiveness of a particular cancer treatment. These trials involve cancer patients taking new cancer drug treatments – before the drug has been approved by the FDA. Patients must volunteer to be tested but most also meet specific criteria to be eligible for testing.<\/span>\n<\/br>\n<\/br>\n\nBy joining a cancer clinical trial, you\u2019re joining a community of fighters, united by a common goal to improve cancer outcomes and offer a brighter future for patients and their loved ones.<\/span>\n<\/br>\n<\/br>\nBelow are some of the current clinical trials affiliated with the Fred Hutchinson Cancer Center at Overlake.<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Enrolling trials: Fred Hutchinson Cancer Center at Overlake<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Contact: Luat Le |lle@seattlecca.org | 206-606-4191<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Protocol name and PI<\/span><\/strong><\/p><\/td>

Indication\/Eligibility<\/span><\/strong><\/p><\/td>

Protocol title<\/span><\/strong><\/p><\/blockquote><\/td><\/tr>

Hockenbery +1 year<\/span><\/p>

Study PI: David \u00a0<\/span><\/p>

Hockenbery<\/span><\/p>

Local PI: Jason Comer<\/span><\/p><\/td>

Treatment na\u00efve, \u00a0colorectal cancer, \u00a0any stage<\/span><\/p>

-no ab, probiotic use<\/span><\/p><\/td>

Features of Gut Microbiome Promoting Colorectal Cancers in \u00a0Different Risk Groups<\/span><\/p>

-Biorepository: stool sample collection study<\/span><\/p><\/td><\/tr>

EA2186 GIANT<\/span><\/p>

PI: David Zhen<\/span><\/p>

Local PI: Jason Comer<\/span><\/p><\/td>

Metastatic \u00a0<\/span><\/p>

pancreatic cancer -70 years or older<\/span><\/p><\/td>

A Randomized Phase II Study of Gemcitabine and NabPaclitaxel \u00a0Compared with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan \u00a0in Older Patients with Treatment Na\u00efve Metastatic Pancreatic Cancer \u00a0(GIANT)<\/span><\/p><\/td><\/tr>

ColoCare,<\/span><\/p>

Consortium PI: \u00a0<\/span><\/p>

William Grady, \u00a0<\/span><\/p>

Christopher Li, Fred \u00a0Hutch<\/span><\/p><\/td>

Colorectal Cancer, \u00a0any stage \u00a0<\/span><\/p>

-allows ab, probiotic \u00a0use<\/span><\/p>

-diagnosed w\/in \u00a0<\/span><\/p>

past 12 months<\/span><\/p>

-intact primary<\/span><\/p><\/td>

Discovery and verification of novel biomarkers of colorectal cancer \u00a0recurrence<\/span><\/p>

-Biorepository: blood sample collection<\/span><\/p><\/td><\/tr><\/tbody><\/table>

Updated 10\/07\/2022<\/span><\/em><\/p>

GU CANCER ENROLLING TRIALS<\/span><\/h2>

Protocol name and PI<\/span><\/p><\/td>

Indication\/Eligibility<\/span><\/p><\/td>

Protocol title<\/span><\/p><\/td><\/tr>

PROMISE<\/span><\/p>

PI: Heather Cheng, SLU<\/span><\/p><\/td>

Any prostate cancer<\/span><\/p><\/td>

PROMISE Registry: A Prostate Cancer Registry of Outcomes and \u00a0Germline Mutations for Improved Survival and Treatment \u00a0Effectiveness<\/span><\/p>

-Free color genomics testing<\/span><\/p><\/td><\/tr>

S1802<\/span><\/p>

PI: Heather Cheng<\/span><\/p><\/td>

Metastatic Prostate \u00a0Cancer<\/span><\/p>

-no more than 28 \u00a0weeks of SST, brain \u00a0mets ineligible, \u00a0<\/span><\/p>

requires urology \u00a0<\/span><\/p>

consult<\/span><\/p><\/td>

Phase III Randomized Trial of Standard Systemic Therapy (SST) \u00a0Versus Standard Systemic Therapy Plus Definitive Treatment \u00a0(Surgery or Radiation) of the Primary Tumor in Metastatic \u00a0Prostate Cancer<\/span><\/p><\/td><\/tr>

CASPAR A031902<\/span><\/p>

Consortium PI: \u00a0<\/span><\/p>

Prakash Varadarajan Local PI: Jason Comer\u201d<\/span><\/p><\/td>

Metastatic \u00a0<\/span><\/p>

Castration Resistant \u00a0Prostate Cancer<\/span><\/p>

-archival tissue \u00a0<\/span><\/p>

available, no prior \u00a0enzalutamide<\/span><\/p><\/td>

A Phase III Trial of Enzulatamide and Rucaparib as a Novel \u00a0Therapy in First-Line Metastatic Castration-Resistant Prostate \u00a0Cancer<\/span><\/p><\/td><\/tr><\/tbody><\/table>

Updated 10\/07\/2022<\/span><\/p>

MALIGNANT HEME ENROLLING TRIALS<\/span><\/h2>

Protocol name and PI<\/span><\/p><\/td>

Indication\/Eligibility<\/span><\/p><\/td>

Protocol title<\/span><\/p><\/td><\/tr>

S1925 EVOLVE<\/span><\/p>

Consortium PI: Mazyar \u00a0Shadman<\/span><\/p>

Local PI: Jason Comer<\/span><\/p><\/td>

Newly diagnosed \u00a0asymptomatic high risk patients with \u00a0chronic lymphocytic \u00a0lymphoma\/small \u00a0lymphocytic \u00a0<\/span><\/p>

lymphoma<\/span><\/p>

-diagnosed w\/in \u00a0<\/span><\/p>

past 12 months<\/span><\/p><\/td>

Randomized, Phase III Study of Early Intervention with \u00a0Venetoclax and Obinutuzumab Versus Delayed Therapy with \u00a0Venetoclax and Obinutuzumab in Newly Diagnosed \u00a0Asymptomatic High-Risk Patients with Chronic Lymphocytic \u00a0Leukemia \/ Small Lymphocytic Lymphoma (CLL\/SLL): EVOLVE \u00a0CLL\/SLL Study<\/span><\/p><\/td><\/tr>

S1918<\/span><\/p>

Consortium PI: Paul \u00a0Martin<\/span><\/p>

Local PI: Jason Comer<\/span><\/p><\/td>

Older patients with \u00a0DLBCL, transformed \u00a0lymphoma, high<\/span><\/p>

grade lymphoma w \u00a0MYC and BCL2 \u00a0<\/span><\/p>

and\/or BCL6 \u00a0<\/span><\/p>

rearrangements<\/span><\/p>

-75 years or older<\/span><\/p><\/td>

A Phase II\/III randomized study of R-miniCHOP with or without \u00a0oral azacitidine (CC-486) in participants age 75 years or older \u00a0with newly diagnosed diffuse large B cell lymphoma, Grade IIIb \u00a0Follicular Lymphoma, transformed lymphoma, and high-grade \u00a0B-cell lymphomas with MYC and BCL2 and\/or BCL6 \u00a0rearrangements<\/span><\/p><\/td><\/tr><\/tbody><\/table>

Updated 10\/07\/2022<\/span><\/p>

LUNG CANCER ENROLLING TRIALS<\/span><\/h2>

Protocol name and PI<\/span><\/p><\/td>

Indication\/Eligibility<\/span><\/p><\/td>

Protocol title<\/span><\/p><\/td><\/tr>

EA5181<\/span><\/p>

Consortium PI: Dan \u00a0Moore<\/span><\/p>

Local PI: Jason Comer<\/span><\/p><\/td>

First line: \u00a0<\/span><\/p>

Unresectable stage \u00a0III (A\/B\/C) NSCLC or \u00a0nodal recurrence \u00a0after surgery for \u00a0<\/span><\/p>

early stage NSCLC<\/span><\/p>

-PFTs required for \u00a0screening<\/span><\/p><\/td>

Randomized Phase III Trial of MEDI4736 (durvalumab) as \u00a0Concurrent and Consolidative Therapy or Consolidative Therapy \u00a0Alone for Unresectable Stage 3 NSCLC<\/span><\/p>

Chemo options: \u00a0<\/span><\/p>

-Cisplatin\/Etoposide<\/span><\/p>

-Pemetrexed\/Cisplatin (non-squamous histology only) \u00a0-Paclitaxel\/Carboplatin<\/span><\/p><\/td><\/tr><\/tbody><\/table>

BREAST CANCER ENROLLING TRIALS<\/span><\/h2>

Protocol name and PI<\/span><\/p><\/td>

Indication\/Eligibility<\/span><\/p><\/td>

Protocol title<\/span><\/p><\/td><\/tr>

Breast Repository \u00a0<\/span><\/p>

Study \u00a0<\/span><\/p>

PI: Eileen Consorti<\/span><\/p><\/td>

Any Overlake Breast \u00a0cancer patients or \u00a0breast patients \u00a0<\/span><\/p>

interested in the \u00a0study<\/span><\/p><\/td>

Breast Repository Study at Overlake<\/span><\/p><\/td><\/tr><\/tbody><\/table>

Updated 10\/07\/2022<\/span><\/p>

\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Clinical Trials An important component of cancer research comes from clinical trials, which are supervised cancer research studies to determine the effectiveness of a particular cancer treatment. These trials involve cancer patients taking new cancer drug treatments – before the drug has been approved by the FDA. Patients must volunteer to be tested but most […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"plain-container","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"_links":{"self":[{"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/pages\/1261"}],"collection":[{"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/comments?post=1261"}],"version-history":[{"count":20,"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/pages\/1261\/revisions"}],"predecessor-version":[{"id":1307,"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/pages\/1261\/revisions\/1307"}],"wp:attachment":[{"href":"https:\/\/lightersideofcancer.com\/wp-json\/wp\/v2\/media?parent=1261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}